Course Description
Biomolecules, DNA Replication and DNA Repair, Control of Gene Expression and regulation Translation and Post translation Protein trafficking and export, Control of cell differentiation, Population and Evolutionary Genetics, Molecular Immunology, Molecular diagnosis in Tropical diseases
Course Goals
The course aims to provide students with the basic and updated knowledge in biomolecules, DNA replication and DNA repair, control of gene expression and regulation, translation and post translation, protein trafficking and export, control of cell differentiation, population and evolutionary genetics, molecular immunology, molecular diagnosis in tropical diseases. Students should be able to appropriately apply the knowledge and molecular techniques to their own research interests.
Course Objectives
1. Understand the principle of molecular cell biology, population genetics and evolution, molecular immunology
2. Apply molecular biology techniques to answer research questions in tropical diseases
3. Dissect scientific principles understanding research works in genomics, transcriptomics, and proteomics
Course-level Learning Outcomes: CLOs
At the end of the course, the students should be able to
CLO1: Describe the principle of molecular cell biology, population genetics and evolution, molecular immunology
CLO2: Choose molecular biology techniques to answer research questions and problem solving in tropical diseases
CLO3: Dissect scientific principles understanding research works in genomics, tran-
sciptomics, and proteomics
4 Comments
Learning Populations and Gene Frequencies can we bring about the targeted treatments or personalized treatments to reduce the amount of alleles produced?.
Thank you for asking.
Personalized medicine is a new field of medicine that uses an individual’s genetic profile to decide how to prevent, diagnose, and treat disease. It’s great that you are so interested in this topic, but I’m afraid that gene frequencies and population genetics are not the best way to answer your question. Feel free to talk more if you want to!
For Plasmodium mutants can mutate and become resistant to treatment malaria. On the other hand, can humans have a genetic mutation that prevents malaria?
That’s a good question. Yes, it is. Malaria is the evolutionary driving force behind sickle-cell disease, thalassemia, glucose-6-phosphatase deficiency, and other erythrocyte defects that together comprise the most common Mendelian diseases of humankind. Feng et al. 2004; Hedrick 2004 proved that HbS, the allele that leads to sickle hemoglobin, is the standard example of balanced polymorphisms in human populations. It is a variant of the HBB gene, which codes for -globin. This variation arose on its own in different places and is still found at a rate of about 10% in many places where malaria is common (Flint et al., 1998). Sickle-cell disease affects people with HbS homozygotes, but people with HbS heterozygotes are 10 times less likely to get serious malaria (Hill et al. 1991; Ackerman et al. 2005).